Masstruct Team

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MASSTRUCT TEAM

Era Chair

Dr Argyris Politis

Principal Investigator

Argyris Politis has obtained degrees from the National Technical University of Athens, Greece and Imperial College London.

He carried out post-doctoral research in Cambridge and Oxford in the laboratory of Prof. Dame Carol Robinson, where he studied the structure and function of protein complexes using mass spectrometry. In 2014, he was appointed as Lecturer at King’s College London where he established his first independent research group focusing on developing mass spectrometry-based strategies to interrogate the structural dynamics of membrane proteins and their complexes. His group has pioneered the study of molecular mechanisms underpinning membrane protein function using the emerging hydrogen deuterium exchange-mass spectrometry (HDX-MS) technology. In 2022, he moved to the University of Manchester as a Reader. His current interests lie in exploring how the native environment and pharmacologically important ligands modulate the structural dynamics of membrane protein. He holds a prestigious EPSRC research Fellowship and since 2025 is an ERA Chair holder leading the MASSTRUCT Project in BSRC “Alexander Fleming”.

Dr Mariam-Eleni Oraiopoulou

Junior Group Leader
Marilena Oraiopoulou is the Junior Group Leader of the lab. She completed her PhD in Computational Neurosciences in 2018 at the Faculty of Medicine, University of Crete, Greece.

Until April 2025, she was a Senior Research Associate at Cancer Research UK – Cambridge Institute and a tutor for the Department of Pathology and Trinity College, University of Cambridge, UK. Earlier, until 2020, she was a Collaborating Researcher at the Institute of Computer Science, Foundation for Research and Technology – Hellas, as well as a visiting lecturer for the University of Crete, Greece.
She has published 15 scientific papers (h8) and has co-supervised 5 PhD, 4 MSc and 5 BSc theses so far. Throughout her career, Marilena seeks for research interdisciplinarity and is an enthusiastic conference speaker. She acts as an outreach ambassador and an advocate for 3Rs in animal research. After specialising in NeuroOncology, she became interested in utilising imaging, computational and analytical techniques to understand cancer pathophysiology. Her research focuses on developing new translational approaches to refine anti-cancer therapeutic efficacy in aggressive cancer types.

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MASSTRUCT TEAM

Post-Doctoral Researchers

Dr Mariam-Eleni Oraiopoulou

Junior Group Leader-Biological Systems

Marilena Oraiopoulou is the Junior Group Leader of biological systems in the lab. She completed her PhD in Computational Neurosciences in 2018 at the Faculty of Medicine, University of Crete, Greece.

Until April 2025, she was a Senior Research Associate at Cancer Research UK – Cambridge Institute and a tutor for the Department of Pathology and Trinity College, University of Cambridge, UK. Earlier, until 2020, she was a Collaborating Researcher at the Institute of Computer Science, Foundation for Research and Technology – Hellas, as well as a visiting lecturer for the University of Crete, Greece.
She has published 15 scientific papers (h8) and has co-supervised 5 PhD, 4 MSc and 5 BSc theses so far. Throughout her career, Marilena seeks for research interdisciplinarity and is an enthusiastic conference speaker. She acts as an outreach ambassador and an advocate for 3Rs in animal research. After specialising in NeuroOncology, she became interested in utilising imaging, computational and analytical techniques to understand cancer pathophysiology. Her research focuses on developing new translational approaches to refine anti-cancer therapeutic efficacy in aggressive cancer types.

Dr Agni
Gavriilidou

Sub-group leader, HDX-MS technology development
Agni F. M. Gavriilidou obtained a chemical engineer degree from the Aristotle University of Thessaloniki, Greece.
She then moved to ETH Zurich, Switzerland in the laboratory of Prof. Renato Zenobi, where she received her Doctor of Sciences studying the structure and function of protein complexes using native mass spectrometry. During her postdoctoral position in OMass Therapeutics, Oxford, UK, she studied pharmaceutical target proteins with native mass spectrometry, DESI and HDX mass spectrometry.

Dr Charalampos Kapsalis

Structural
Biochemistry

Haris Kapsalis is a postdoctoral researcher at the lab. He holds a Bachelor’s degree in Chemistry from National and Kapodistrian University of Athens and an MSc in Public Health and Nutrition from Harokopio University of Athens.

In 2020, he earned his PhD in Biology from St. Andrews University, UK, where his research focused on structural and functional studies of membrane proteins and their interactions with membranes and lipids. From 2020 to 2024, he worked as a Postdoctoral Researcher at the National Hellenic Research Foundation (Greece), where he conducted a biophysical study of aggregation-prone proteins for the G. Skretas Lab.

Artemis Lioupi

Sub-group leader, Technology

Artemis Lioupi received her BSc in Chemistry (2017) and MSc in Chemical Analysis–Bioanalysis (2019) from the Aristotle University of Thessaloniki.
She holds a PhD (2022) in Analytical Chemistry, with a specialization in metabolomics and lipidomics. Her research focuses on the development and validation of analytical methods for the determination of various drugs and biomarkers in diverse matrices (biofluids, tissues, food), using advanced analytical techniques such as LC-MS/MS (HRMS, TIMS-TOF) and GC-MS/MS. Artemis is experienced in the use of advanced statistical software for data mining and metabolite annotation. She has participated in over 20 scientific conferences and co-authored 14 publications (h-index: 8) in peer-reviewed scientific journals. She has received competitive research grants and participated in European research projects in collaboration with academic institutions, contributing to the development of innovative analytical platforms for studying complex biological systems.
Dr Mariam-Eleni Oraiopoulou

Junior Group Leader-Biological Systems

Marilena Oraiopoulou is the Junior Group Leader of biological systems in the lab. She completed her PhD in Computational Neurosciences in 2018 at the Faculty of Medicine, University of Crete, Greece.

Until April 2025, she was a Senior Research Associate at Cancer Research UK – Cambridge Institute and a tutor for the Department of Pathology and Trinity College, University of Cambridge, UK. Earlier, until 2020, she was a Collaborating Researcher at the Institute of Computer Science, Foundation for Research and Technology – Hellas, as well as a visiting lecturer for the University of Crete, Greece.
She has published 15 scientific papers (h8) and has co-supervised 5 PhD, 4 MSc and 5 BSc theses so far. Throughout her career, Marilena seeks for research interdisciplinarity and is an enthusiastic conference speaker. She acts as an outreach ambassador and an advocate for 3Rs in animal research. After specialising in NeuroOncology, she became interested in utilising imaging, computational and analytical techniques to understand cancer pathophysiology. Her research focuses on developing new translational approaches to refine anti-cancer therapeutic efficacy in aggressive cancer types.

Dr Agni
Gavriilidou

Sub-group leader, HDX-MS technology development
Agni F. M. Gavriilidou obtained a chemical engineer degree from the Aristotle University of Thessaloniki, Greece.
She then moved to ETH Zurich, Switzerland in the laboratory of Prof. Renato Zenobi, where she received her Doctor of Sciences studying the structure and function of protein complexes using native mass spectrometry. During her postdoctoral position in OMass Therapeutics, Oxford, UK, she studied pharmaceutical target proteins with native mass spectrometry, DESI and HDX mass spectrometry.

Dr Charalampos Kapsalis

Structural Biochemistry

Haris Kapsalis is a postdoctoral researcher at the lab. He holds a Bachelor’s degree in Chemistry from National and Kapodistrian University of Athens and an MSc in Public Health and Nutrition from Harokopio University of Athens.

In 2020, he earned his PhD in Biology from St. Andrews University, UK, where his research focused on structural and functional studies of membrane proteins and their interactions with membranes and lipids. From 2020 to 2024, he worked as a Postdoctoral Researcher at the National Hellenic Research Foundation (Greece), where he conducted a biophysical study of aggregation-prone proteins for the G. Skretas Lab.
Artemis Lioupi
Sub-group leader, Technology
Artemis Lioupi received her BSc in Chemistry (2017) and MSc in Chemical Analysis–Bioanalysis (2019) from the Aristotle University of Thessaloniki.
She holds a PhD (2022) in Analytical Chemistry, with a specialization in metabolomics and lipidomics. Her research focuses on the development and validation of analytical methods for the determination of various drugs and biomarkers in diverse matrices (biofluids, tissues, food), using advanced analytical techniques such as LC-MS/MS (HRMS, TIMS-TOF) and GC-MS/MS. Artemis is experienced in the use of advanced statistical software for data mining and metabolite annotation. She has participated in over 20 scientific conferences and co-authored 14 publications (h-index: 8) in peer-reviewed scientific journals. She has received competitive research grants and participated in European research projects in collaboration with academic institutions, contributing to the development of innovative analytical platforms for studying complex biological systems.
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MASSTRUCT TEAM

Communications Manager

Dimitra Chrysomalli

Communications Manager

Dimitra Chrysomalli is the Science Communication Manager for MASSTRUCT Project.

She holds a Bachelor Degree in the Department of French Language and Literature from the National and Kapodistrian University of Athens. In 2003, she was awarded her M.A. in Applied Linguistics at Birkbeck College, University of London. During the past two decades, she has extensive experience as a communication manager in education and learning. Specifically, she has been responsible for developing dissemination and communication strategies and tools for various educational projects concerning the English, French and German language. Aside from her communication manager background, she has previous experience as HR manager and Executive PA to the President of a major Greek pharmaceutical company, namely Apivita.

Dr Mariam-Eleni Oraiopoulou

Junior Group Leader
Marilena Oraiopoulou is the Junior Group Leader of the lab. She completed her PhD in Computational Neurosciences in 2018 at the Faculty of Medicine, University of Crete, Greece.

Until April 2025, she was a Senior Research Associate at Cancer Research UK – Cambridge Institute and a tutor for the Department of Pathology and Trinity College, University of Cambridge, UK. Earlier, until 2020, she was a Collaborating Researcher at the Institute of Computer Science, Foundation for Research and Technology – Hellas, as well as a visiting lecturer for the University of Crete, Greece.
She has published 15 scientific papers (h8) and has co-supervised 5 PhD, 4 MSc and 5 BSc theses so far. Throughout her career, Marilena seeks for research interdisciplinarity and is an enthusiastic conference speaker. She acts as an outreach ambassador and an advocate for 3Rs in animal research. After specialising in NeuroOncology, she became interested in utilising imaging, computational and analytical techniques to understand cancer pathophysiology. Her research focuses on developing new translational approaches to refine anti-cancer therapeutic efficacy in aggressive cancer types.

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MASSTRUCT TEAM

Scientific Advisory Board

Prof Justin Benesch
University of Oxford
Justin Benesch is Professor of Biophysical Chemistry at the University of Oxford and a Tutorial Fellow in Physical Chemistry at University College, Oxford.
His research is internationally recognised for advancing innovative biophysical approaches to understanding protein behaviour, with a particular emphasis on mass measurement technologies integrated with complementary experimental techniques, simulations, and rigorous thermodynamic and kinetic analysis. These methods have reshaped our understanding of how proteins assemble, interact, and evolve. A founder of Refeyn Ltd, Justin has played a pivotal role in establishing and translating mass photometry into a powerful tool for the life sciences, enabling precise molecular mass measurements in solution. His contributions have been acknowledged with several prestigious awards, including a Royal Society University Research Fellowship, and the Norman Heatley Award from the Royal Society of Chemistry, and the Alfred Tissières Award from the Cell Stress Society International.
Babis Kalodimos
St Jude Hospital, TN, USA
In his role as Chair of the Department of Structural BIology and Joseph Simone Endowed Chair in Basic Research, Dr. Charalampos Babis Kalodimos has positioned St. Jude as a world leader in Structural Biology research.

Dr. Kalodimos received his PhD in 1999 from the Institute Curie in Paris and began exploring the world of biomolecular NMR as a postdoc with Dr. Robert Kaplan in Utrecht, The Netherlands. Recruited to St. Jude in 2017, Dr. Kalodimos continues an already distinguished career, highlighted by numerous Young Investigator Awards, the 2017 Raymond and Beverly Sackler International Prize in the Physical Sciences, and election as a 2020 Biophysical Society Fellow.

Prof Dr Nina Morgner
Goethe University, Frankfurt
Nina Morgner is a Professor of Physical Chemistry in Goethe University, Frankfurt.
Her interest lies in the investigation of non-covalently bound biological complexes using mass spectrometry methods. A second aspect is the further development of a new mass spectrometry method, which can complement existing methods: LILBID (Laser Induced Liquid Bead Ion Desorption). Since 2024, she is the Managing director of the Institute for Theoretical and Physical Chemistry, Goethe University, Frankfurt.
Professor Vassilis Koronakis
University of Cambridge
Vassilis Koronakis, Professor of Molecular Biology at the University of Cambridge and fellow at Wolfson College Cambridge, has made seminal contributions to our understanding of prokaryotic and eukaryotic cell biology in health and disease.
Biological processes at membranes are fundamental to living cells, but when Koronakis began his work, membrane proteins and complexes were very poorly understood and regarded as experimentally intractable. By establishing a series of innovative approaches that combine membrane protein biochemistry with molecular, structural and cell biology, he has provided comprehensive, vivid pictures of the mechanisms underlying the behaviour of bacterial pathogens. He has revealed how bacteria synthesise, activate and secrete membrane-targeted pore-forming toxins, how they colonise mammalian cell surfaces, how others force entry into cells and establish an intracellular niche, and how they become multiply resistant to antibiotics. These creative approaches are crucial to understanding how bacteria establish successful infections in humans and animals and uncover new targets for the development of anti-infectives. His pioneering research on the structure and function of tripartite multidrug efflux pumps spanning the cell envelope featured landmark advances that changed how we view membrane protein structure and transport, and they are now a standard of biology textbooks. Remarkably, the same biochemical rigour has allowed him to describe with precision how bacterial virulence effectors usurp the host cytoskeleton by dual mechanisms of direct actin remodelling and manipulation of cell signalling. His publications are of unremitting high-quality, often prompting commentaries. Professor Koronakis is an exceptional, original and innovative biomedical scientist who is an international leader in molecular and cellular investigation of important problems in medical microbiology.
Dr Idlir Liko
Senior Director of Technology and Founder, OMass Therapeutics
Idlir Liko is the Technology Director and founder of OMass Therapeutics.
He received a Master’s Degree from ETH Zurich in 2012 and DPhil from the University of Oxford in 2015, supervised by Prof. Dame Carol Robinson, where he focused on the effect ligands and PTMs have on structure and stability of membrane proteins. His work has been featured in many high-impact publications. He has a wealth of experience in structural MS working in close collaboration with biotech and pharmaceutical companies. In 2016, he co-founded the company and since then, he has played a key role in transferring our technology from academia to industry.
Professor
Kasper Rand
University of Copenhagen
Prof. Kasper Rand is an internationally recognized expert in the use of the hydrogen-deuterium exchange mass spectrometry (HDX-MS) technique to study the conformation and dynamics of proteins.

His research focuses on analysis of the conformational dynamics of proteins to understand their function and thus provide the framework for developing new and better drugs. In particular, his group at University of Copenhagen (https://pharmacy.ku.dk/research/protein-analysis-group/) uses HDX-MS to study the conformation, dynamics and interactions of complex protein systems that are difficult to access by other methods. For a number of years, he has been at the forefront of applying and developing the HDX-MS method to tackle ever more challenging protein systems at an increasing level of detail, for instance, membrane proteins, complex glycoproteins and antibody interactions. He is a founding member of the International Society for HDX-MS (http://hdxms.net/) and served as chairman of the board of this society from its founding in 2016 to 2022.

Dr Malvina Papanastasiou

Broad Institute, USA

Malvina Papanastasiou is a Group Leader and Research Scientist at the Broad Institute of MIT & Harvard spearheading structural proteomics initiatives using hydrogen/deuterium exchange (HDX) and cross-linking mass spectrometry (XL-MS).
She has more than fifteen years of experience leading interdisciplinary efforts in drug discovery, epigenetics, immunology, and cancer research. Her work has been instrumental in understanding protein structure/function relationships, characterizing drug-target interactions, and elucidating their downstream effects in health and disease. She contributes her expertise to multiple high-profile research consortia funded by NIH and HHMI. She is currently a Vice-Chair of the International Society of HDX-MS. As a recognized expert in her field, Malvina has been frequently invited as a selected speaker at scientific conferences and has co-organized international symposia focused on structural proteomics. Prior to joining the Broad Institute in 2016, Malvina gained experience in MS-based proteomics and protein structure/function by HDX-MS. She undertook postdoctoral research at the Center for Drug Discovery at Northeastern University to develop MS-based approaches to characterize cannabinoid receptor-ligand interactions. She subsequently worked as a research scientist at the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology – Hellas (FORTH), Heraklion, Greece, working on MS-based membrane proteomics. During this term, she also served as an EMBO visiting fellow at the University of Southern Denmark to study the structure of proteins involved in bacterial protein translocation by HDX-MS. She subsequently undertook a postdoctoral fellowship at the Perelman School of Medicine (UPenn) investigating protein structure and protein-ligand interactions of components of the human complement system. Malvina obtained a M.S. and Ph.D. in chemistry at Manchester Metropolitan University, as well as a B.Sc. in environmental sciences from the University of the Aegean.