Scientific Mission & Impact
THE PROJECT
Scientific mission & impact
The research group aims to develop the tools and technologies to advance bioscience discovery and innovation. This will in turn improve our fundamental knowledge in better understanding biological processes underpinning human health and disease. A key impact of MASSTRUCT and the associated Group will be to drive the necessary structural and scientific changes to improve people’s health, and to protect, transform and sustain our economy, society, and environment.
Specifically, the Group focuses on the development and application of structural MS techniques to interrogate the structure, dynamics, and function of challenging membrane proteins. Membrane proteins constitute the main targets of most known drugs. However, structural knowledge of these important biomolecules is limited by the lack of tools that can accurately monitor their conformational states and structural motions in physiologically relevant conditions. Research in the Group will address such challenges by developing the emerging HDX-MS technology to interrogate the dynamic signatures of membrane proteins and their complexes.
